Newgeography.com has a great new listing of the top North American metropolitan areas for knowledge-based high-tech industries based on 19 categories of data. The top five include:
1. Silicon Valley, California
2. Seattle-Bellevue-Everett, Washington
3. Cambridge, Newton and Framingham, Massachusetts
4. Washington-Arlington-Alexandria, D.C. and Virginia
5. Los Angeles–Long Beach–Glendale, California

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